Alimentary System

Stomach, Forestomach - Inflammation

    Narrative
    Stomach, Forestomach - Inflammation, Suppurative in a male F344/N rat from a chronic study. This suppurative inflammation is associated with an ulcer.
    Stomach, Forestomach - Inflammation, Chronic in a female B6C3F1 mouse from a chronic study. Numerous lymphocytes are present in the submucosa and serosa, often forming nodules or follicles similar to gut-associated lymphoid tissue. The overlying epithelium is hyperplastic and contains suppurative inflammation.
    Stomach, Forestomach - Inflammation, Chronic in a female B6C3F1 mouse from a chronic study. Minimal chronic inflammation is present in the submucosa.
    Stomach, Forestomach - Inflammation, Chronic active in a female B6C3F1 mouse from a chronic study. Numerous lymphocytes, macrophages, and neutrophils are present within the submucosa; the overlying squamous epithelium of the stomach is hyperplastic and ulcerated and contains suppurative inflammation.
    Stomach, Forestomach - Inflammation, Chronic active in a male F344/N rat from a chronic study. Numerous lymphocytes, plasma cells, and neutrophils are present within the submucosa; the overlying squamous epithelium of the stomach is hyperplastic.

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC