Alimentary System

Stomach, Forestomach - Ulcer

    Narrative
    Stomach, Forestomach - Ulcer in a male F344/N rat from a chronic study. A portion of the epithelium is absent, exposing the underlying submucosa.
    Stomach, Forestomach - Ulcer in a male F344/N rat from a chronic study (higher magnification of Figure 1). There is some inflammation associated with the ulcer.
    Stomach, Forestomach - Ulcer in a male F344/N rat from a chronic study. A large portion of the epithelium is absent, exposing the underlying submucosa.
    Stomach, Forestomach - Ulcer in a male F344/N rat from a chronic study (higher magnification of Figure 3). A significant amount inflammation is associated with the ulcer, as well as hyperplasia of the adjacent epithelium.
    Stomach, Forestomach - Ulcer in a male B6C3F1 mouse from a subchronic study. A large portion of the epithelium is absent, exposing the underlying submucosa.

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC