Stomach, Glandular Stomach, Epithelium - Hyperplasia
comment:Glandular stomach lesions are quite rare in NTP mouse studies. Hyperplasia of the glandular stomach mucosa is not common in controls but may be seen in regenerative hyperplasia, such as at the margin of an ulcer or erosion. Glandular hyperplasia is characterized by an increase in density of glands within the mucosa. In rats, hyperplasia may be a preneoplastic lesion. Focal hyperplasia is seen occasionally in mice. However, in mice this is not considered to be a preneoplastic change; the incidence is not increased in studies with adenocarcinomas of the glandular stomach, and progression from focal hyperplasia to adenocarcinoma has not been observed.
recommendation:Hyperplasia of the glandular stomach is diagnosed and graded based on the extent of the lesion and the number of cells within the gastric glands. When atypical hyperplasia is diagnosed, the atypical features should be clearly described in the pathology narrative (see Stomach, Glandular Stomach, Epithelium - Hyperplasia, Atypical). Associated lesions, such as necrosis and inflammation, should be diagnosed separately. If the hyperplasia is thought to be secondary to necrosis or inflammation (e.g., regenerative), it should be made clear in the pathology narrative.
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