Alimentary System

Stomach, Glandular Stomach, Epithelium - Hyperplasia

    Narrative
    Stomach, Glandular stomach, Epithelium - Hyperplasia in female F344/N rat from a chronic study. There is a focal area of hyperplasia in the mucosa.
    Stomach, Glandular stomach, Epithelium - Hyperplasia in a female F344/N rat from a chronic study (higher magnification of Figure 1). The basophilic cells are smaller and more crowded, and there slight compression of the adjacent mucosa.
    Stomach, Glandular stomach, Epithelium - Hyperplasia in a male B6C3F1 mouse from a chronic study. There is an expansile focus of basophilic cells with glandular dilation (arrows).
    Stomach, Glandular stomach, Epithelium - Hyperplasia in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 3). The nuclei are crowded, but there is little compression of the adjacent mucosa.
    Stomach, Glandular stomach, Epithelium - Hyperplasia in female F344/NTac rat from a subchronic study. There is a focus of proliferating epithelial cells (arrow) extending into the submucosa.
    Stomach, Glandular stomach, Epithelium - Hyperplasia in female F344/NTac rat from a subchronic study (higher magnification of Figure 5). The hyperplastic cells are smaller and more basophilic than the normal glandular epithelial cells.
    Stomach, Glandular stomach, Epithelium - Hyperplasia in a male F344/N rat from a chronic study. There are numerous foci of hyperplasia within the mucosa (arrows).
    Stomach, Glandular stomach, Epithelium - Hyperplasia in a male F344/N rat from a chronic study (higher magnification of Figure 7). The hyperplastic cells are small, crowded, and basophilic.

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC