Stomach, Glandular Stomach - Erosion

comment:
Spontaneous occurrence of erosion of the glandular stomach is uncommon in NTP studies in mice and F344/N rats. Erosions are seen primarily in treated rats. An erosion ( Figure 1

recommendation:
Erosion of the glandular stomach should be diagnosed and graded based on the extent and distribution of the lesions. Edema, inflammation, and hyperplasia of the adjacent epithelium should not be diagnosed separately unless they are a prominent component of the lesion. Necrosis of epithelium is diagnosed instead of erosion if the necrotic epithelium is still present and at least partially attached to the underlying viable epithelium.related links:
Stomach, Glandular Stomach - Ulcerreferences:
Ackerman SH, Hofer MA, Weiner H. 1975. Age at maternal separation and gastric erosion susceptibility in the rat. Psychosom Med 37:180-183. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/1079604
Betton GR. 1998. The digestive system I: The gastrointestinal tract and exocrine pancreas. In: Target Organ Pathology (Turton J, Hooson J, eds). Taylor and Francis, London, 29-60.
Brown HR, Hardisty JF. 1990. Oral cavity, esophagus and stomach. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 9-30. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Hirose M, Hakoi K, Takahashi S, Hoshiya T, Akagi K, Lin C, Saito K, Kaneko H, Shirai T. 1999. Sequential morphological and biological changes in the glandular stomach induced by oral administration of catechol to male F344 rats. Toxicol Pathol 27:448-455. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/10485826
Leininger JR, Jokinen MP, Dangler CA, Whiteley LO. 1999. Oral cavity, esophagus, and stomach. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 29-48. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Web page last updated on: November 17, 2014