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  • Stomach, Glandular Stomach - Hemorrhage

    Image of hemorrhage in the glandular stomach from a female B6C3F1 mouse in a subchronic study
    Stomach, Glandular stomach - Hemorrhage in a female B6C3F1 mouse from a subchronic study. There is hemorrhage in the mucosa.
    Figure 1 of 4
    Image of hemorrhage in the glandular stomach from a male F344/N rat in a chronic study
    Stomach, Glandular stomach - Hemorrhage in a male F344/N rat from a chronic study. There is hemorrhage in the submucosa.
    Figure 2 of 4
    Image of hemorrhage in the glandular stomach from a male F344/N rat in a chronic study
    Stomach, Glandular stomach - Hemorrhage in a male F344/N rat from a chronic study. There is hemorrhage in the mucosa and a vascular thrombus in the submucosa (arrow).
    Figure 3 of 4
    Image of hemorrhage in the glandular stomach from a male F344/N rat in a chronic study
    Stomach, Glandular stomach - Hemorrhage in a male F344/N rat from a chronic study (higher magnification of Figure 3). There is hemorrhage in the mucosa and a vascular thrombus in the submucosa (arrow).
    Figure 4 of 4
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    comment:

    Hemorrhage characterized by free red blood cells in the lamina propria ( Figure 1image opens in a pop-up window ), submucosa ( Figure 2image opens in a pop-up window ) or muscular wall of the stomach is uncommon and usually secondary to treatment-related inflammation, erosion, ulceration, necrosis, or thrombosis ( Figure 3image opens in a pop-up window and Figure 4image opens in a pop-up window , arrows).

    recommendation:

    Hemorrhage should be diagnosed and graded. Hemorrhage in an area of necrosis or inflammation is usually not diagnosed separately, unless it is a prominent component of the lesion, but should be described in the pathology narrative.

    references:

    MacKenzie WF, Alison R. 1990. Heart. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 461-472.
    Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563