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Stomach, Glandular Stomach, Epithelium - Hyperplasia, Atypical

Image of hyperplasia, atypical in the glandular stomach epithelium from a female B6C3F1 mouse in a chronic study
Stomach, Glandular stomach, Epithelium - Hyperplasia, Atypical in a female B6C3F1 mouse from a chronic study. There is an expansile focus of hyperplasia within the mucosa (arrow).
Figure 1 of 2
Image of hyperplasia, atypical in the glandular stomach epithelium from a female B6C3F1 mouse in a chronic study
Stomach, Glandular stomach, Epithelium - Hyperplasia, Atypical in a female B6C3F1 mouse from a chronic study (higher magnification of Figure 1). The epithelial cells within this hyperplastic focus are pleomorphic.
Figure 2 of 2
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Glandular stomach lesions are quite rare in NTP mouse studies. In the stomach, the principal features of atypical hyperplasia include cellular atypia, abnormal differentiation, and disorganized mucosal architecture. Cellular atypia is characterized by nuclear pleomorphism, hyperchromasia and stratification of nuclei, increased nuclear-cytoplasmic ratio, and loss of cellular and nuclear polarity. Abnormal differentiation is distinguished by reduction or alteration in the normal secretory products of the mucosa. The features of disorganized mucosal architecture include irregularity of crypt structure, "back-to-back" glands, budding and branching of crypts and intraluminal, and surface papillary growths. Atypical hyperplasia can be found in the glandular stomach of rats treated with carcinogens.


Atypical hyperplasia is diagnosed and graded based on the degree of proliferation, disorganization, and atypia of the glandular epithelial cells. When atypical hyperplasia is diagnosed, the atypical features should be clearly described in the pathology narrative. Associated lesions, such as necrosis and inflammation, should be diagnosed separately. If the hyperplasia is thought to be secondary to necrosis or inflammation (e.g., regenerative), this should be made clear in the pathology narrative.


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