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    • Stomach, Glandular Stomach - Metaplasia, Intestinal

    Image of metaplasia, intestinal in the glandular stomach from a male F344/N rat in a chronic study
    Stomach, Glandular stomach - Metaplasia, Intestinal in a male F344/N rat from a chronic study. Metaplasia of fundic glands to intestinal glands (arrow).
    Figure 1 of 2
    Image of metaplasia, intestinal in the glandular stomach from a male F344/N rat in a chronic study
    Stomach, Glandular stomach - Metaplasia, Intestinal in a male F344/N rat from a chronic study. Metaplasia of fundic glands to intestinal glands (arrow).
    Figure 2 of 2
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    comment:

    Intestinal metaplasia consists of areas of gastric mucosa morphologically similar to the intestine ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ). The metaplastic mucosal lining may have crypts, variably developed villi, goblet cells, paneth cells, and absorptive cells and may be enzymatically similar to the intestine. Chronic inflammation can result in metaplasia of the gastric pitsto a mucus-type hyperplastic epithelium, similar to that of the intestine. Notice the microvilli on surface of epithelial cells in Figure 2image opens in a pop-up window . In some cases, intestinal metaplasia may be associated with gastric neoplasia.

    recommendation:

    Whenever present, intestinal metaplasia should be diagnosed and graded based on the number of metaplastic glands present.

    references:

    Bertram TA, Markovits JE, Juliana MM. 1996. Non-proliferative lesions of the alimentary canal in rats GI-1. In Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-16.
    Full Text: https://www.toxpath.org/docs/SSNDC/GINonproliferativeRat.pdf

    Blaser BJ, Parsonnet J. 1994. Parasitism by the "slow bacterium" Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J Clin Invest 94:4-8.
    Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC296275/

    Leininger JR, Jokinen MP, Dangler CA, Whiteley LO. 1999. Oral cavity, esophagus, and stomach. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 29-48.
    Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

    National Toxicology Program. 1992. NTP TR-399. Toxicology and Carcinogenesis Studies of Titanocene Dichloride (CAS No. 1271-19-8) in F344/N Rats (Gavage Studies). NTP, Research Triangle Park, NC.
    Abstract: http://ntp.niehs.nih.gov/go/12249

    Shirai T, Takahashi M, Fukushima S, Ito N. 1985. Marked epithelial hyperplasia of the rat glandular stomach induced by long-term administration of iodoacetamide. Acta Pathol Jpn 35:35-43.
    Abstract: http://www.ncbi.nlm.nih.gov/pubmed/4003096

    Ward JM. 1985. Proliferative lesions of the glandular stomach and liver in F-344 rats fed diets containing Aroclor 1254. Environ Health Perspect 60:89-95.
    Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568552/

    Watanabe H, Naito M, Ito A. 1984. The effect of sex differences on induction of intestinal metaplasia in rats. Acta Pathol Jpn 32:305-312.

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    Web page last updated on: November 17, 2014