Stomach, Glandular Stomach - Mineralization

comment:
Mineralization characterized by focal aggregates or concretions of densely blue-staining mineral is fairly common in the H&E-stained sections from the stomachs of aged rats, where they are associated with cystic dilation of the gastric glands; mice and hamsters occasionally show similar changes. Gastric mineralization may become marked in rodents when there is disturbance in mineral metabolism, particularly with chronic progressive renal disease and uremia due to altered calcium-phosphorus metabolism and hyperparathyroidism. These changes are characterized by mineralization of the vessels throughout the gastric fundus, muscular tunics, and interstitium in a band paralleling the parietal-cell-rich region of the mucosa ( Figure 1

recommendation:
Mineralization should be diagnosed and graded depending on the extent of mineralization. Associated lesions, such as inflammation or degeneration of gastric epithelial cells, that are secondary to the mineralization should not be diagnosed separately but should be described in the narrative.references:
Bertram TA, Markovits JE, Juliana MM. 1996. Non-proliferative lesions of the alimentary canal in rats GI-1. In Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-16. Full Text: https://www.toxpath.org/docs/SSNDC/GINonproliferativeRat.pdf
Brown HR, Hardisty JF. 1990. Oral cavity, esophagus and stomach. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 9-30. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Greaves P. 2007. Digestive system. In: Histopathology of Preclinical Toxicity Studies, 3rd ed. Academic Press, London, 334-456. Abstract: http://www.sciencedirect.com/science/book/9780444527714
Leininger JR, Jokinen MP, Dangler CA, Whiteley LO. 1999. Oral cavity, esophagus, and stomach. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 29-48. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Newman SJ, Confer AW, Panciera RJ. 2007. Urinary system. In: Pathologic Basis of Veterinary Disease, 4th ed (McGavin MD, Zachary JF, eds). Mosby, St Louis, MO, 613-691.
Web page last updated on: November 17, 2014