Alimentary System

Stomach, Glandular Stomach - Necrosis

    Narrative
    Stomach, Glandular stomach - Necrosis in a female B6C3F1 mouse from a subchronic study. There is loss of glandular epithelial cells within the mucosa.
    Stomach, Glandular stomach - Necrosis in a female B6C3F1 mouse from a subchronic study (higher magnification of Figure 1). There is loss of glandular epithelial cells and scattered pyknotic debris within the mucosa.
    Stomach, Glandular stomach - Necrosis in a male F344/N rat from a chronic study. There is a thrombosed vessel in the submucosa (arrow), resulting in an area of necrosis (infarct) with hemorrhage.
    Stomach, Glandular stomach - Necrosis in a male F344/N rat from a chronic study. There is a thrombosed vessel in the submucosa (arrow), resulting in a well-demarcated area of necrosis (infarct) involving the mucosa and submucosa.

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC