Alimentary System

Stomach, Glandular Stomach, Neuroendocrine Cell - Hyperplasia

    Narrative
    Stomach, Glandular stomach, Neuroendocrine cell - Hyperplasia in a female F344/N rat from a chronic study. The mucosa is expanded by a pale focus of cells.
    Stomach, Glandular stomach, Neuroendocrine cell - Hyperplasia in a female F344/N rat from a chronic study (higher magnification of Figure 1). The hyperplastic cells have small cytoplasmic vacuoles and are grouped in to small clusters separated by a fine vascular stroma.
    Stomach, Glandular stomach, Neuroendocrine cell - Hyperplasia in a female F344/N rat from a chronic study. The mucosal glands are separated by smaller cells with fine cytoplasmic vacuoles.
    Stomach, Glandular stomach, Neuroendocrine cell - Hyperplasia in a female F344/N rat from a chronic study (Sevier-Munger stain). The cells separating the glands stain positively with a silver stain.
    Stomach, Glandular stomach, Neuroendocrine cell - Hyperplasia in a female F344/N rat from a chronic study (Chromagranin A immunohistochemistry). The cells separating the glands are immunopositive for Chromagranin A.
    Stomach, Glandular stomach, Neuroendocrine cell - Hyperplasia in a female F344/N rat from a chronic study (Sevier-Munger stain). The gastric glands are separated by pale-staining cells.

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC