Stomach, Glandular Stomach - Pigment





comment:
Focal to multifocal areas of pigment accumulation in epithelial cells of the glandular mucosa are occasionally noted ( Figure 1





recommendation:
Whenever present, this change should be diagnosed as "pigment" and graded. Severity grading depends on the number and size of pigmented areas present and on the density of pigment accumulation. The specific type of pigmented material should not be specified in the diagnosis unless special stains or other means are used for definitive diagnosis. However, in the narrative the pathologist may provide an opinion as to the type of pigment that is present.references:
Bertram TA, Markovits JE, Juliana MM. 1996. Non-proliferative lesions of the alimentary canal in rats GI-1. In Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-16. Full Text: https://www.toxpath.org/docs/SSNDC/GINonproliferativeRat.pdf
Betton GR. 1998. The digestive system I: The gastrointestinal tract and exocrine pancreas. In: Target Organ Pathology (Turton J, Hooson J, eds). Taylor and Francis, London, 29-60.
Myers RK, McGavin MD. 2007. Cellular and tissue responses to injury. In: Pathologic Basis of Veterinary Disease, 4th ed (McGavin MD, Zachary JF, eds). Mosby, St Louis, MO, 3-62.
National Toxicology Program. 1992. NTP TR-409. Toxicology and Carcinogenesis Studies of Quercetin (CAS No. 117-39-5) in F344/N Rats (Feed Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/7698
Pizzolato P. 1976. Formalin pigment (acid hematin) and related pigments. Am J Med Technol 42:436-440. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/790956
Web page last updated on: November 17, 2014