Stomach, Glandular Stomach - Pigment
comment:Focal to multifocal areas of pigment accumulation in epithelial cells of the glandular mucosa are occasionally noted ( Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 and Figure 6 ). In some cases the occurrence is sporadic and of unknown origin and is considered incidental or artifactual. Examples of pigmented material are breakdown products of hemoglobin (hematin, hematin-like, parasite hematin, hemosiderin), lipofuscin, and test article. Hemosiderin (golden-brown pigment), often within macrophages, is the most common. The presence of acid hematin-like pigment in the mucosa is suggestive of an ulcerative or erosive process not in the plane of histologic section.
recommendation:Whenever present, this change should be diagnosed as "pigment" and graded. Severity grading depends on the number and size of pigmented areas present and on the density of pigment accumulation. The specific type of pigmented material should not be specified in the diagnosis unless special stains or other means are used for definitive diagnosis. However, in the narrative the pathologist may provide an opinion as to the type of pigment that is present.
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