Stomach, Glandular Stomach - Ulcer

comment:
Spontaneous occurrence of ulceration of the glandular stomach is uncommon in NTP studies in mice and F344/N rats. Ulceration is seen primarily in treated rats and has been experimentally induced as a model for ulcer in humans. An ulcer ( Figure 1

recommendation:
Ulceration of the glandular stomach should be diagnosed and graded based upon the extent and distribution of the lesion. Edema, inflammation, and hyperplasia of the adjacent epithelium should not diagnosed separately unless they are a prominent component of the lesion. Necrosis of epithelium is diagnosed instead of ulceration if the necrotic epithelium is still present and at least partially attached to the underlying lamina propria.related links:
Stomach, Glandular Stomach - Erosionreferences:
Ackerman SH, Hofer MA, Weiner H. 1975. Age at maternal separation and gastric erosion susceptibility in the rat. Psychosom Med 37:180-183. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/1079604
Betton GR. 1998. The digestive system I: The gastrointestinal tract and exocrine pancreas. In: Target Organ Pathology (Turton J, Hooson J, eds). Taylor and Francis, London, 29-60.
Brown HR, Hardisty JF. 1990. Oral cavity, esophagus and stomach. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 9-30. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Hirose M, Hakoi K, Takahashi S, Hoshiya T, Akagi K, Lin C, Saito K, Kaneko H, Shirai T. 1999. Sequential morphological and biological changes in the glandular stomach induced by oral administration of catechol to male F344 rats. Toxicol Pathol 27:448-455. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/10485826
Leininger JR, Jokinen MP, Dangler CA, Whiteley LO. 1999. Oral cavity, esophagus, and stomach. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 29-48. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Web page last updated on: November 17, 2014