Stomach, Glandular Stomach, Epithelium - Vacuolation, Cytoplasmic

comment:
Cytoplasmic vacuolation is generally considered to be an early form of degeneration. Cytoplasmic vacuolization ( Figure 1

recommendation:
Whenever present, this change should be diagnosed as "glandular stomach, epithelium - vacuolation, cytoplasmic" and graded based on the degree of cellular swelling and extent and number of areas affected. If there is other evidence of degeneration (e.g., sloughing or loss of cells, or nuclear changes), the lesion may be diagnosed as degeneration. If two or more lesions (e.g., cytoplasmic vacuolation, vesicles, bulla, necrosis, ulcers, inflammation) are considered different manifestations of the same lesion, the study pathologist should explain this in detail in the narrative. If inflammation is a prominent component of the lesion, then it should be diagnosed and graded separately.references:
Haggerty HG, Warner WA, Comereski CR, Peden WM, Mezza LE, Damle BD, Siegall CB, Davidson TJ. 1999. BR96 sFv-PE40 immunotoxin: Nonclinical safety assessment. Toxicol Pathol 27:87-94. Full Text: http://tpx.sagepub.com/content/27/1/87.full.pdf
Myers RK, McGavin MD. 2007. Cellular and tissue responses to injury. In: Pathologic Basis of Veterinary Disease, 4th ed (McGavin MD, Zachary JF, eds). Mosby, St Louis, MO, 3-62.
National Toxicology Program. 2007. NTP TOX-72. Toxicity Studies of Sodium Dichromate Dihydrate (CAS No. 7789-12-0) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice and Male Balb/c and am3-C57BL/6 Mice. NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/11170
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