Alimentary System

Oral Mucosa - Hyperplasia, Cystic, Keratinizing

    Narrative
    Oral mucosa - Hyperplasia, Cystic, Keratinizing in a male Harlan Sprague-Dawley rat from a chronic study. The keratin-filled cyst is distorting normal architecture, including that of the nasal cavity.
    Oral mucosa - Hyperplasia, Cystic, Keratinizing in a male Harlan Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). The keratin-filled cyst with destruction of maxillary bone is shown.
    Oral mucosa - Hyperplasia, Cystic, Keratinizing in a male Harlan Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). The wall of the cyst is fairly uniform.
    Oral mucosa - Hyperplasia, Cystic, Keratinizing in a male Harlan Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). The epithelial cells in the wall of the cyst are normal.

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC