Salivary Gland, Parotid - Basophilic Hypertrophic Focus

Salivary gland, Parotid - Basophilic hypertrophic focus in a female F344/N rat from a chronic study. A focus of hypertrophied cells with increased basophilia is present (arrow).
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Salivary gland, Parotid - Basophilic hypertrophic focus in a female F344/N rat from a chronic study (higher magnification of Figure 1). A focus of hypertrophied cells with increased basophilia is present (arrow).
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Salivary gland, Parotid - Basophilic hypertrophic focus in a male F344/N rat from a chronic study. Multiple foci of hypertrophied cells with increased basophilia are present (arrows).
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Salivary gland, Parotid - Basophilic hypertrophic focus in a female F344/N rat from a chronic study. Multiple foci of hypertrophied cells with increased basophilia are present (arrows).
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comment:
Basophilic hypertrophic foci of the salivary glands have been found only in the parotid gland in mice and rats and usually occur singly ( Figure 1




recommendation:
When a single focus is present, it should be diagnosed as "basophilic hypertrophic focus." Multiple foci should be diagnosed as "basophilic hypertrophic focus, multiple." Severity grading is not necessary, but if an increase in size or number of foci is correlated with chemical exposure, a grading scale should be applied that takes into account both the size and number of foci in each animal.references:
Botts S, Jokinen M, Gaillard ET, Elwell MR, Mann PC. 1999. Salivary, Harderian, and lacrimal glands. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 49-80. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Neuenschwander SB, Elwell MR. 1990. Salivary glands. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 31-42. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Web page last updated on: November 17, 2014