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  • Salivary Gland, Duct - Cyst

    Image of cyst in the salivary gland duct from a female B6C3F1 mouse in a chronic study
    Salivary gland, Duct - Cyst in a female B6C3F1 mouse from a chronic study. The cyst is roughly circular, and the epithelium is somewhat flattened.
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    comment:

    Salivary gland duct cysts tend to involve one or a few ducts and usually have a circular profile ( Figure 1image opens in a pop-up window ), whereas ductular dilation of salivary glands is typically more generalized (involving multiple ducts), and the ducts tend to have an irregular profile (see Salivary Gland, Duct - Dilation). Cysts may be caused by obstruction of a duct by calculi, trauma, or foreign body. Ductular dilation and ductular cysts are not common in NTP rodent studies.

    recommendation:

    Duct cysts should be diagnosed but are generally not graded unless there is a treatment-related effect on the size of the cysts. If squamous metaplasia of the ductal epithelium is present, it should be diagnosed and graded separately.

    references:

    Germann PG, Ockert D, Tuch K. 1995. Oropharyngeal granulomas and tracheal cartilage degeneration in Fischer-344 rats. Toxicol Pathol 23:349-355.
    Abstract: http://www.ncbi.nlm.nih.gov/pubmed/7659957

    National Toxicology Program. 1989. NTP TR-350. Toxicology and Carcinogenesis Studies of Tribromomethane (Bromoform) (CAS No. 75-25-2) in Fe44/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
    Abstract: http://ntp.niehs.nih.gov/go/6961

    Neuenschwander SB, Elwell MR. 1990. Salivary glands. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 31-42.
    Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563