Salivary Gland, Duct - Cyst
comment:Salivary gland duct cysts tend to involve one or a few ducts and usually have a circular profile ( Figure 1 ), whereas ductular dilation of salivary glands is typically more generalized (involving multiple ducts), and the ducts tend to have an irregular profile (see Salivary Gland, Duct - Dilation). Cysts may be caused by obstruction of a duct by calculi, trauma, or foreign body. Ductular dilation and ductular cysts are not common in NTP rodent studies.
recommendation:Duct cysts should be diagnosed but are generally not graded unless there is a treatment-related effect on the size of the cysts. If squamous metaplasia of the ductal epithelium is present, it should be diagnosed and graded separately.
related links:Salivary Gland, Duct - Dilation
Germann PG, Ockert D, Tuch K. 1995. Oropharyngeal granulomas and tracheal cartilage degeneration in Fischer-344 rats. Toxicol Pathol 23:349-355. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/7659957
National Toxicology Program. 1989. NTP TR-350. Toxicology and Carcinogenesis Studies of Tribromomethane (Bromoform) (CAS No. 75-25-2) in Fe44/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/6961
Neuenschwander SB, Elwell MR. 1990. Salivary glands. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 31-42. Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Web page last updated on: November 24, 2014