Salivary Gland - Hyperplasia




comment:
Hyperplasia of the salivary gland can be acinar, ductal ( Figure 2





recommendation:
Hyperplasia of the salivary gland should be diagnosed and graded whenever present. If the hyperplasia is limited to the ducts or to the acini, then the appropriate site modifier (duct or acinus) should be included in the diagnosis. If both the ducts and acini are hyperplastic, then no site modifier should be used, but it should be made clear in the pathology narrative that both components are affected. The modifier "regenerative" can be added to the hyperplasia diagnosis when the hyperplasia is occurring in areas of the gland in which there has been tissue damage. Severity grading is based on the size of the gland (lobules) or number of hyperplastic glands or ducts affected. Associated lesions such as inflammation, fibrosis, or necrosis should not be diagnosed separately unless warranted by severity.references:
Carthew P, Slinger RP. 1981. Diagnosis of sialodacryoadenitis virus infection of rats in a virulent enzootic outbreak. Lab Anim 15:339-342. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6281552
Cotroneo E, Proctor GB, Carpenter GH. 2010. Regeneration of acinar cells following ligation of rat submandibular gland retraces the embryonic-perinatal pathway of cytodifferentiation. Differentiation 79:120-130. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20056310
Cotroneo E, Proctor GB, Paterson KL, Carpenter GH. 2008. Early markers of regeneration following ductal ligation in rat submandibular gland. Cell Tissue Res 332:227-235. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/18335244
Elmore S, Lanning L, Allison N, Vallant M, Nyska A. 2006. The transduction of rat submandibular glands by an adenoviral vector carrying the human growth hormone gene is associated with limited and reversible changes at the infusion site. Toxicol Pathol 34:385-392. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/16844666
Neuenschwander SB, Elwell MR. 1990. Salivary glands. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 31-42. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Reindel JF, Pilcher GD, Gough AW, Haskins JR, de la Iglesia FA. 1996. Recombinant human epidermal growth factor1-48-induced structural changes in the digestive tract of cynomolgus monkeys (Macaca fascicularis). Toxicol Pathol 24:669-679. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/9082544
Takahashi S, Nakamura S, Domon T, Yamamoto T, Wakita M. 2005. Active participation of apoptosis and mitosis in sublingual gland regeneration of the rat following release from duct ligation. J Mol Histol 36:199-205. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/15900411
Web page last updated on: November 17, 2014