Salivary Gland - Infiltration, Cellular

Salivary gland - Infiltration, Cellular, Lymphocyte in a female B6C3F1 mouse from a chronic study. The cellular infiltrates (arrows) are more deeply basophilic than the glandular tissue.
Figure 1 of 2
comment:
Infiltrates in the salivary gland can include small mature lymphocytes, eosinophils, mast cells, histiocytes, and nondegenerate granulocytes. Infiltrates of mononuclear cells, primarily lymphocytes, sometimes admixed with a few plasma cells, occur commonly in the salivary glands of B6C3F1 mice ( Figure 1

recommendation:
Whenever present, an infiltrate of cells in the salivary gland should be diagnosed as recorded as "infiltration, cellular" with the appropriate cell type indicated (i.e., lymphocyte, eosinophil, histiocyte, etc.). Severity grading is based on the number of cells infiltrating the salivary gland. If lymphocytes (or other infiltrating cells) are considered a component of atrophy, they should not be diagnosed but should be described in the narrative with the atrophy.references:
Botts S, Jokinen M, Gaillard ET, Elwell MR, Mann PC. 1999. Salivary, Harderian, and lacrimal glands. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 49-80. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Greaves P. 2007. Digestive system. In: Histopathology of Preclinical Toxicity Studies, 3rd ed. Academic Press, London, 334-456. Abstract: http://www.sciencedirect.com/science/book/9780444527714
Neuenschwander SB, Elwell MR. 1990. Salivary glands. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 31-42. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
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