Alimentary System

Salivary Gland - Necrosis

    Narrative
    Salivary gland - Necrosis in a male F344/N rat from a subchronic study. There is necrosis of the acinar cells (arrow) with inflammation.
    Salivary gland - Necrosis in a male F344/N rat from a subchronic study. There is necrosis of the acinar cells (arrow) with chronic active inflammation.
    Salivary gland - Necrosis in a female F344/N rat from a subchronic study. There is necrosis of an entire lobe of the salivary gland (arrow), consistent with an infarct.
    Salivary gland - Necrosis in a female F344/N rat from a subchronic study. There is necrosis of all the components of the salivary gland (consistent with an infarct), with inflammatory cells, mostly neutrophils.

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC