Salivary Gland - Necrosis



comment:
Necrosis may be characterized either by scattered single-cell necrosis or by locally extensive areas of necrosis involving contiguous cells or structures. Single-cell necrosis can present as cell shrinkage, condensation of nuclear chromatin and cytoplasm, convolution of the cell, and the presence of apoptotic bodies. Acinar necrosis can present as focal to multifocal areas characterized by tissue that is paler than the surrounding viable tissue, consisting of swollen cells with variable degrees of eosinophilia, hyalinized cytoplasm, vacuolated cytoplasm, nuclear pyknosis, karyolysis, and/or karyorrhexis with associated cellular debris ( Figure 1



recommendation:
Whenever present, necrosis should be diagnosed and graded based on the extent of the necrosis. Secondary lesions, such as inflammation or hemorrhage, are not diagnosed separately unless warranted by severity. Infarcts should be diagnosed as necrosis, but the pathology narrative should state that the lesion is consistent with an infarct.references:
Botts S, Jokinen M, Gaillard ET, Elwell MR, Mann PC. 1999. Salivary, Harderian, and lacrimal glands. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 49-80. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Elmore S, Lanning L, Allison N, Vallant M, Nyska A. 2006. The transduction of rat submandibular glands by an adenoviral vector carrying the human growth hormone gene is associated with limited and reversible changes at the infusion site. Toxicol Pathol 34:385-392. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/16844666
Neuenschwander SB, Elwell MR. 1990. Salivary glands. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 31-42. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Web page last updated on: November 17, 2014