Alimentary System

Salivary Gland, Submandibular, Duct - Cytoplasmic Alteration

    Narrative
    Normal submandibular salivary gland in a female B6C3F1 mouse from a chronic study. The arrow indicates a convoluted salivary gland duct.
    Normal submandibular salivary gland in a male B6C3F1 mouse from a chronic study. The convoluted salivary gland ducts (arrow) contain more eosinophilic, cytoplasmic granules in males than in females (see Figure 1).
    Salivary gland, Duct - Cytoplasmic alteration in a female B6C3F1 mouse from a chronic study. In this submandibular salivary gland, there are increased numbers of eosinophilic, cytoplasmic granules in the ducts (arrow), reminiscent of the male ducts.

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC