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Salivary Gland, Submandibular, Duct - Cytoplasmic Alteration

Image of cytoplasmic alteration in the submandibular salivary gland duct from a female B6C3F1 mouse in a chronic study
Normal submandibular salivary gland in a female B6C3F1 mouse from a chronic study. The arrow indicates a convoluted salivary gland duct.
Figure 1 of 3
Image of cytoplasmic alteration in the submandibular salivary gland duct from a male B6C3F1 mouse in a chronic study
Normal submandibular salivary gland in a male B6C3F1 mouse from a chronic study. The convoluted salivary gland ducts (arrow) contain more eosinophilic, cytoplasmic granules in males than in females (see Figure 1).
Figure 2 of 3
Image of cytoplasmic alteration in the submandibular salivary gland duct from a female B6C3F1 mouse in a chronic study
Salivary gland, Duct - Cytoplasmic alteration in a female B6C3F1 mouse from a chronic study. In this submandibular salivary gland, there are increased numbers of eosinophilic, cytoplasmic granules in the ducts (arrow), reminiscent of the male ducts.
Figure 3 of 3
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comment:

For a discussion on the sexual dimorphism of the salivary gland in rodents, please see the Introduction for this chapter. Examples of the normal female ( Figure 1image opens in a pop-up window ) and male ( Figure 2image opens in a pop-up window ) salivary gland ducts are provided here for comparison. In females, cytoplasmic alteration of the submandibular salivary gland is characterized by an increase in granularity of the convoluted (granular) ducts ( Figure 3image opens in a pop-up window ), such that it appears similar to the normal male salivary gland ducts ( Figure 2image opens in a pop-up window ). This change is due to a masculinizing effect of certain chemicals or hormones. A concomitant metaplasia of the parietal epithelium of Bowman’s capsule in the kidneys from flattened to cuboidal can also occur in the female mouse when exposed to masculinizing agents. Cytoplasmic alteration is often a subtle change requiring careful scrutiny.

recommendation:

Cytoplasmic alteration should be diagnosed and graded based on the degree of increase in eosinophilic intracytoplasmic granules and number of convoluted (granular) ducts affected.

references:

Botts S, Jokinen M, Gaillard ET, Elwell MR, Mann PC. 1999. Salivary, Harderian, and lacrimal glands. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 49-80.
Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

Seely JC. 1999. Kidney. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 207-234.
Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.