Tongue - Fibrosis

Tongue - Fibrosis in a male F344/N rat from a subchronic study. There is an area of fibrosis with associated inflammation in the tongue (arrow).
Figure 1 of 2
comment:
Fibrosis ( Figure 1

recommendation:
When it occurs in absence of other lesions, fibrosis should be diagnosed and graded. When it is a component of chronic inflammation, fibrosis should not be diagnosed separately unless it is particularly prominent or disproportionately severe relative to the severity of the inflammation, or if the pathologist feels it is an important lesion that needs to be highlighted. Associated lesions, if prominent, should be diagnosed separately (e.g., necrosis, inflammation).references:
Ackermann MR. 2007. Chronic inflammation and wound healing. In: Pathologic Basis of Veterinary Disease, 4th ed (McGavin MD, Zachary JF, eds). Mosby, St Louis, MO, 101-152.
Bertram TA, Markovits JE, Juliana MM. 1996. Non-proliferative lesions of the alimentary canal in rats GI-1. In: Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-16. Full Text: https://www.toxpath.org/docs/SSNDC/GINonproliferativeRat.pdf
Web page last updated on: November 24, 2014