Alimentary System

Tongue - Hyperkeratosis

    Narrative
    Tongue - Hyperkeratosis in a female F344/N rat from a chronic study. The keratin layer on the surface of the tongue is thickened (arrow).
    Tongue - Hyperkeratosis in a female F344/N rat from a chronic study. The keratin layer on the surface of the tongue is thickened (arrow).
    Tongue - Hyperkeratosis in a female F344/N rat from a chronic study (higher magnification of Figure 1). The hyperkeratosis is orthokeratotic, lacking nuclei.
    Tongue - Hyperkeratosis in a female F344/N rat from a chronic study (higher magnification of Figure 1). The hyperkeratosis is orthokeratotic, lacking nuclei.

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC