Alimentary System

Tongue - Inflammation

    Narrative
    Tongue - Inflammation, Chronic active in a male F344/N rat from a chronic study. The muscle bundles are separated by inflammatory cells and fluid.
    Tongue - Inflammation, Chronic active in a male F344/N rat from a chronic study (higher magnification of Figure 1). Inflammatory cells comprise lymphocytes, macrophages, and neutrophils.
    Tongue - Inflammation, Suppurative in a female F344/N rat from a chronic study. There is a large abscess in the tongue.
    Tongue - Inflammation, Suppurative in a female F344/N rat from a chronic study (higher magnification of Figure 3). The center of the abscess is composed of degenerate neutrophils and cellular debris and is surrounded by large, activated macrophages, lymphocytes, and fibrous connective tissue.
    Tongue - Inflammation, Suppurative in a male Swiss CD-1 mouse from a chronic study. There is a large, abscess in the tongue.
    Tongue - Inflammation, Suppurative in a male Swiss CD-1 mouse from a chronic study (higher magnification of Figure 5). The center of the abscess is composed of degenerate neutrophils and cellular debris and contains a fragment of foreign material (arrow).
    Tongue - Inflammation, Granulomatous in a female F344/N rat from a chronic study. There is a large, subepithelial area of inflammation.
    Tongue - Inflammation, Granulomatous in a female F344/N rat from a chronic study (higher magnification of Figure 7). The majority of the inflammatory cells are large, epithelioid macrophages, with fewer lymphocytes and neutrophils.
    Tongue - Inflammation, Granulomatous in a male Swiss CD-1 mouse from a chronic study. There is a subepithelial focus of inflammation in the tongue.
    Tongue - Inflammation, Granulomatous in a male Swiss CD-1 mouse from a chronic study (higher magnification of Figure 9). The center of the inflammatory focus is composed of epithelioid macrophages with fewer neutrophils and lymphocytes and contains a hair shaft (arrow).

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC