Tongue - Ulcer

comment:
Ulcers and erosions can occur anywhere in the gastrointestinal tract, including the tongue. An erosion involves the loss of superficial epithelium of the mucosa, whereas an ulcer ( Figure 1

recommendation:
Ulceration and erosion of the tongue should be diagnosed and graded. Edema, inflammation, and hyperplasia of the adjacent epithelium should not generally be diagnosed separately unless they are prominent components of the lesion. Necrosis of the epithelium is diagnosed instead of erosion or ulceration if the necrotic epithelium is still present and attached to the underlying lamina propria.references:
Bertram TA, Markovits JE, Juliana MM. 1996. Non-proliferative lesions of the alimentary canal in rats GI-1. In: Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-16. Full Text: https://www.toxpath.org/docs/SSNDC/GINonproliferativeRat.pdf
Comereski CR, Peden WM, Davidson TJ, Warner GL, Hirth RS, Frantz JD. 1994. BR96-doxorubicin conjugate (BMS-182248) versus doxorubicin: A comparative toxicity assessment in rats. Toxicol Pathol 22:473-488. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/7899776
Leininger JR, Jokinen MP, Dangler CA, Whiteley LO. 1999. Oral cavity, esophagus, and stomach. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 29-48. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
National Toxicology Program. 2008. NTP TR-546. Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate (CAS No. 7789-12-0) in F344 rats and B6C3F1 Mice (Drinking Water Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/29323
Web page last updated on: November 24, 2014