Alimentary System

Tooth, Incisor - Degeneration

    Narrative
    Tooth, Incisor - Degeneration in a female Harlan Sprague-Dawley rat from a subchronic study. Odontoblast degeneration and dentin niche formation (arrows) are present.
    Tooth, Incisor - Degeneration in a female Harlan Sprague-Dawley rat from a subchronic study (higher magnification of Figure 1). There is thinning of the dentin layer and loss of and degeneration of odontoblasts (arrow) in a dentin niche.
    Tooth, Incisor - Degeneration in a female Harlan Sprague-Dawley rat from a subchronic study. Abnormal dentin and osteodentin production (arrow) are present.
    Tooth, Incisor - Degeneration in a female Harlan Sprague-Dawley rat from a subchronic study. Abnormal dentin and osteodentin production (arrow) are present.

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC