Cardiovascular System

Blood Vessel - Amyloid

    Narrative
    Liver, Artery - Amyloid in a male Swiss Webster mouse from a chronic study. The walls of multiple hepatic arteries are thickened by eosinophilic material (amyloid, arrows).
    Liver, Artery - Amyloid in a male Swiss Webster mouse from a chronic study (higher magnification of Figure 1). The tunica media of a small artery is thickened by extracellular, eosinophilic material (amyloid, arrows).
    Normal aorta in a male B6C3F1/N mouse from a chronic study.
    Lung, Artery - Amyloid in a male Swiss Webster mouse in a chronic study. The walls of the pulmonary arteries contain eosinophilic, acellular material (arrows).
    Lung, Artery - Amyloid in a male Swiss Webster mouse in a chronic study (higher magnification of Figure 3). Eosinophilic, acellular material expands the wall of a pulmonary artery (arrows).
    Liver, Artery - Amyloid in a male B6C3F1 mouse from a chronic study. Amyloid expands the wall of a central vein (arrows).
    Liver, Vein - Amyloid in a male B6C3F1 mouse from a chronic study. Congo Red staining of amyloid creates apple green birefringence under polarized light (arrows).

    Authors:

    Crystal L. Johnson, DVM, DACVP
    Veterinary Pathologist II
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Paul W. Snyder, DVM, PhD, Diplomate ACVP, Fellow IATP
    Manager, EPL Midwest
    Senior Pathologist
    Experimental Pathology Laboratories, Inc. 
    West Lafayette, IN

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC