Cardiovascular System

Blood Vessel - Metaplasia

    Narrative
    Brain, Artery - Metaplasia, Osseous in an F344/N male rat from a chronic study. There is deeply basophilic bone (arrows) in a vessel.
    Brain, Artery - Metaplasia, Osseous in an F344/N male rat from a chronic study (higher magnification of Figure 1). There are mature bone fragments in the wall of an artery (arrows).
    Aorta - Metaplasia, Osseous in a female B6C3F1/N mouse from a subchronic study. There is mature bone (arrow) in the wall of the aorta.
    Aorta - Metaplasia, Osseous in a female B6C3F1/N mouse from a subchronic study (higher magnification of Figure 3). There are mature bone marrow elements within the metastatic bone (arrows).

    Authors:

    Crystal L. Johnson, DVM, DACVP
    Veterinary Pathologist II
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Paul W. Snyder, DVM, PhD, Diplomate ACVP, Fellow IATP
    Manager, EPL Midwest
    Senior Pathologist
    Experimental Pathology Laboratories, Inc. 
    West Lafayette, IN

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC