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Blood Vessel - Necrosis

Image of necrosis in the mammary gland, arteriole from a female F344/N rat in a chronic study
Mammary gland, Arteriole - Necrosis in a female F344/N rat from a subchronic study. Loss of cells in multiple arteriolar segments is apparent (arrows).
Figure 1 of 2
Image of necrosis in the mammary gland, arteriole from a female F344/N rat in a chronic study
Mammary gland, Arteriole - Necrosis in a female F344/N rat from a subchronic study (higher magnification of Figure 1). Loss of cells and disorganization of the wall of multiple arteriolar segments is apparent (arrows).
Figure 2 of 2
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Necrosis of blood vessels ( Figure 1image opens in a pop-up window  and Figure 2image opens in a pop-up window ) in laboratory animals is most often seen as one component of the spectrum of lesions of polyarteritis and is rarely present as an individual lesion without other associated changes. Distinguishing between vascular necrosis resulting from spontaneous polyarteritis nodosa and necrosis resulting from compound administration may be difficult (see Blood Vessel - Polyarteritis Nodosa for a description). Necrosis generally affects the tunica media of small to medium-sized arteries. Affected vessels have decreased numbers of cells, either segmentally or circumferentially. The walls of affected vessels are generally more eosinophilic and often have a homogeneous appearance. Degenerate collagen and smooth muscle contribute to the increased eosinophilia. With time, lesions of vascular necrosis are generally accompanied by an intense inflammatory infiltrate and may give rise to thrombi.

Administration of cardiovascular drugs such as vasodilators and vasoconstrictor substances may also cause medial necrosis of the same vascular beds. The anatomic location of arterial necrosis differs with the type of compound administered.


Vascular necrosis should be diagnosed and graded whenever present, unless is considered a component of polyarteritis nodosa (see Blood Vessel - Polyarteritis Nodosa). The organ in which it occurs should be recorded as the site, and the type of vessel affected (e.g., arteriole, vein) should be indicated using a site modifier. If the type of blood vessel cannot be determined, the site modifier "blood vessel" may be used. Lesions in protocol-required great vessels, such as aorta, should be recorded with the blood vessel as the site (e.g., Aorta - Necrosis). Grading should be based on the number of vessels affected in the organ and the extent of the lesion. If the necrosis is thought to be secondary to another lesion in that organ (e.g., inflammation), or if it is part of a larger necrotic lesion affecting the organ, vascular necrosis should not be diagnosed separately unless warranted by severity.


Clemo FAS, Evering WE, Snyder PW, Albassam MA. 2003. Differentiating spontaneous from drug-induced vascular injury in the dog. Toxicol Pathol 31:25-31.
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