Cardiovascular System

Blood Vessel - Polyarteritis Nodosa

    Narrative
    Prostate - Polyarteritis nodosa in a male B6C3F1/N mouse from a subchronic study. Abundant inflammatory cells surround a prostatic artery (arrows).
    Pancreas - Polyarteritis nodosa in a male Wistar Han rat from a chronic study. Inflammation of a muscular artery is present in the pancreas (arrows).
    Stomach, Glandular stomach - Polyarteritis nodosa in a male B6C3F1/N mouse from a chronic study. A thick band of inflammatory cells surrounds a small artery (arrows).
    Stomach, Glandular stomach - Polyarteritis nodosa in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). A hypereosinophilic band of necrotic tissue is present in the vessel wall (arrow).
    Mesentery - Polyarteritis nodosa in a female F344/N rat from a chronic study. Multiple areas of fibrosis (arrows) are present along the length of a medium-sized muscular artery in the mesentery.
    Mesentery - Polyarteritis nodosa in a female F344/N rat from a chronic study (higher magnification of Figure 5). The adventitia of a mesenteric artery (arrow) is thickened by proliferation of fibroblasts and collagen.
    Mesentery - Polyarteritis nodosa in a female F344/N rat from a chronic study (higher magnification of Figure 5). There is fibrosis of the adventitia of a mesenteric artery.
    Pancreas - Polyarteritis nodosa in a female Wistar Han rat from a chronic study. A medium-sized muscular artery has an eosinophilic, hyalinized appearance indicative of necrosis.
    Pancreas - Polyarteritis nodosa in a female Wistar Han rat from a chronic study. Necrosis and fibrin are present in the tunica media (arrows) of a pancreatic artery surrounded by inflammatory cells.

    Authors:

    Crystal L. Johnson, DVM, DACVP
    Veterinary Pathologist II
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Paul W. Snyder, DVM, PhD, Diplomate ACVP, Fellow IATP
    Manager, EPL Midwest
    Senior Pathologist
    Experimental Pathology Laboratories, Inc. 
    West Lafayette, IN

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC