Cardiovascular System

Heart - Inflammation

    Narrative
    Heart, Valve - Inflammation, Acute in a female F344/N rat from a chronic study. Neutrophils (arrows) are present within a valve.
    Heart, Valve - Inflammation, Suppurative in a female F344/N rat from a chronic study. Suppurative inflammation is present in the mitral valve (arrows).
    Heart, Valve - Inflammation, Suppurative in a female F344/N rat from a chronic study (higher magnification of Figure 2). Suppurative inflammation of the mitral valve has aggregates of bacteria (arrows).
    Heart, Valve - Inflammation, Chronic in a female F344/N rat from a chronic study. Mixed inflammatory cells are present within the thickened mitral valve (arrows).
    Heart, Valve - Inflammation, Chronic in a female F344/N rat from a chronic study (higher magnification of Figure 4). Mixed inflammatory cells and proliferation of mesenchymal cells result in thickening of the mitral valve.
    Heart, Valve - Inflammation, Chronic in a female F344/N rat from a chronic study (higher magnification of Figure 4). Lymphocytes, macrophages, and plasma cells with proliferating mesenchymal cells are present in the mitral valve.
    Heart - Inflammation, Chronic-active in a male F2 generation CD1 mouse. Inflammation of the heart along the endocardium consists primarily of neutrophils and macrophages.
    Heart - Inflammation, Chronic-active in a male B6C3F1/N mouse from a chronic study. Chronic active inflammation is present along the epicardial surface of the heart.

    Authors:

    Crystal L. Johnson, DVM, DACVP
    Veterinary Pathologist II
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Brian Berridge, DVM, PhD, DACVP
    Director, WW Animal Research Strategy
    GlaxoSmithKline R&D
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC