Endocrine System

Adrenal Gland - Amyloid

    Narrative
    Adrenal gland, Cortex - Amyloid in a male B6C3F1/N mouse from a chronic study. There is homogeneous, amorphous, pale eosinophilic material (amyloid, A) expanding the zona fasciculata and zona reticularis; C = cortex, M = medulla.
    Adrenal gland, Cortex - Amyloid in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). The homogeneous, amorphous, pale eosinophilic material (amyloid, A) in the zona fasciculata and zona reticularis separates and replaces the cortical cells; C = cortex, M = medulla.
    Adrenal gland, Cortex - Amyloid in a male Swiss Webster mouse from a chronic study. A thick circumferential band of homogeneous, amorphous, pale eosinophilic material (amyloid, A) largely replaces the cells of the zona reticularis; C = cortex, M = medulla.
    Adrenal gland, Cortex - Amyloid in a female B6C3F1/N mouse from a chronic study. Abundant, homogeneous, amorphous, pale eosinophilic material (amyloid, A) separates and replaces the cells inner cortex; C = cortex, M = medulla.
    Adrenal gland, Cortex - Amyloid in a female B6C3F1/N mouse from a chronic study (same animal as in Figure 4). Amyloid deposits in the inner cortex (arrow) stained with Congo red appear dull reddish orange under nonpolarized light.
    Adrenal gland, Cortex - Amyloid in a female B6C3F1/N mouse from a chronic study (same animal as in Figure 4). Amyloid deposits in the inner cortex (arrow) stained with Congo red have a characteristic �apple green� birefringence under polarized light.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    Veterinary Pathologist, In Vivo Animal Core
    Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist/Assistant Pathology Program Manager
    Comparative Molecular Pathology Division
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Gordon Flake, MD
    Staff Scientist
    NTP Pathologist
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC