Adrenal Gland, Cortex - Cellular Atypia


comment:
Atypia of adrenocortical cells ( Figure 1


Foci of atypical adrenocortical cells must be differentiated from adrenocortical adenomas. Adenomas typically cause compression of adjacent tissue, and there is loss of the normal radial arrangement of the cords; these features are not present in foci of cellular atypia.
recommendation:
Adrenal gland, Cortex - Cellular atypia should be diagnosed and assigned a severity grade. The diagnosis should be used in cases where a large proportion of the cells in a hypertrophic focus also have nuclei that exhibit features of atypia as described above. In such cases, only the diagnosis of "Cellular atypia" (and not "Hypertrophy") should be recorded. When the number of atypical cells in a focus of hypertrophy does not warrant a diagnosis of atypia (the pathologist must use his or her judgment to determine if this is the case), then hypertrophy should be diagnosed and the few scattered atypical cells described in the narrative. In cases where atypical cells occur in a significant number of cells in an area of cortical hyperplasia, the diagnosis should be "Hyperplasia, Atypical" (see Adrenal Gland - Hyperplasia). If cellular atypia is seen in both adrenal glands, the modifier "bilateral" should be added to the diagnosis (lesions are assumed to be unilateral unless otherwise indicated).related links:
Adrenal Gland - Hyperplasiareferences:
National Toxicology Program. 1992. NTP TR-388. Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CAS No. 96-45-7) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle, Park, NC. Abstract: https://ntp.niehs.nih.gov/go/12227
National Toxicology Program. 1993. NTP TR-404. Toxicology and Carcinogenesis Studies of 5,5-Diphenylhydantoin (Phenytoin) (CAS No. 57-41-0) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle, Park, NC. Abstract: https://ntp.niehs.nih.gov/go/7688
National Toxicology Program. 2001. NTP TR-479. Toxicology and Carcinogenesis Studies of Coconut Oil Acid Diethanolamine Condensate (CAS No. 68603-42-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies). NTP, Research Triangle, Park, NC. Abstract: https://ntp.niehs.nih.gov/go/9760
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