Endocrine System

Adrenal Gland, Cortex - Degeneration, Cystic

    Narrative
    Adrenal gland, Cortex - Degeneration, Cystic in a female Sprague-Dawley rat from a chronic study. The cortex is distended by dilated spaces filled with proteinaceous fluid and/or blood (CD).
    Adrenal gland, Cortex - Degeneration, Cystic in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). Cystic degeneration is characterized by dilated spaces filled with proteinaceous fluid and/or blood and scattered vacuolated cortical cells.
    Adrenal gland, Cortex - Degeneration, Cystic in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). Cavitated spaces (C) delineated by attenuated cortical cells (arrow) are filled with proteinaceous fluid.
    Adrenal gland, Cortex - Degeneration, Cystic in a female Sprague-Dawley rat from a chronic study. Multiple irregular cavitations (asterisk) formed by loss of cortical cells expand and distort the cortex (C) and compress the adjacent medulla (M).
    Adrenal gland, Cortex - Degeneration, Cystic in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 4). Multiple irregular cavitations (asterisk) formed by loss of cortical cells contain proteinaceous fluid.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    Veterinary Pathologist, In Vivo Animal Core
    Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist/Assistant Pathology Program Manager
    Comparative Molecular Pathology Division
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Gordon Flake, MD
    Staff Scientist
    NTP Pathologist
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC