Endocrine System

Adrenal Gland, Cortex - Hyperplasia, Subcapsular

    Narrative
    Adrenal gland, Cortex - Hyperplasia, Subcapsular in a female Tg.AC (FVB/N) hemizygous mouse from a subchronic study. Early-stage subcapsular cell hyperplasia (SCH) is characterized by subcapsular foci of small, basophilic cells that extend into the zona fasciculata (arrow).
    Adrenal gland, Cortex - Hyperplasia, Subcapsular in a female Tg.AC (FVB/N) hemizygous mouse from a subchronic study (higher magnification of Figure 1). Early-stage subcapsular hyperplasia is composed primarily of smaller, more basophilic, fusiform, type A cells that extend into the zona fasciculate.
    Adrenal gland, Cortex - Hyperplasia, Subcapsular in a female B6C3F1/N mouse from a chronic study. Multiple foci of basophilic hyperplastic cells (arrows) are present in the subcapsular region.
    Adrenal gland, Cortex - Hyperplasia, Subcapsular in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). The subcapsular hyperplasia is characterized by proliferation of smaller, fusiform, basophilic type A (A) cells with nests of larger, paler, polygonal type B cells (B).
    Adrenal gland, Cortex - Hyperplasia, Subcapsular in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). Smaller, fusiform, basophilic type A cells are crowded together in a focus of subcapsular hyperplasia.
    Adrenal gland, Cortex - Hyperplasia, Subcapsular in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). Nests of larger, paler, polygonal type B cells are present in a focus of subcapsular hyperplasia.
    Adrenal gland, Cortex - Hyperplasia, Subcapsular in a female B6C3F1/N mouse from a chronic study. Extensive subcapsular hyperplasia (arrows) forms a thick, almost circumferential band around the adrenal gland.
    Adrenal gland, Cortex - Hyperplasia, Subcapsular in a male B6C3F1/N mouse from a chronic study. A large subcapsular hyperplastic lesion is composed predominantly of polygonal type B cells (B) with fewer fusiform type A cells (A). M = medulla.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    Veterinary Pathologist, In Vivo Animal Core
    Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist/Assistant Pathology Program Manager
    Comparative Molecular Pathology Division
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Gordon Flake, MD
    Staff Scientist
    NTP Pathologist
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC