Endocrine System

Adrenal Gland, Cortex - Hypertrophy

    Narrative
    Adrenal gland, Cortex - Hypertrophy in a female Sprague-Dawley rat from a chronic study. There is a well-demarcated, noncompressive focal area in which the cells are enlarged (FH). C = cortex, M = medulla.
    Adrenal gland, Cortex - Hypertrophy in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). The cells in this focus of hypertrophy (FH) have increased amounts of pale eosinophilic cytoplasm.
    Adrenal gland, Cortex - Hypertrophy in a male B6C3F1/N/N mouse from a chronic study. There is a focus of enlarged cells (arrows) in the cortex that slightly compresses the adjacent parenchyma; there is also subcapsular hyperplasia (SCH).
    Adrenal gland, Cortex - Hypertrophy in a male B6C3F1/N/N mouse from a chronic study (higher magnification of Figure 3). The cells in this focus of hypertrophy (FH) have increased amounts of pale eosinophilic cytoplasm and slightly enlarged nuclei.
    Adrenal gland, Cortex - Hypertrophy in a male F344/N rat from a chronic study. Diffuse cortical hypertrophy results in pronounced overall gland enlargement. M = medulla.
    Adrenal gland, Cortex - Hypertrophy in a male F344/N rat from a chronic study (higher magnification of Figure 5). The hypertrophic cortical cells (arrows) have increased cytoplasmic volume.
    Adrenal gland, Cortex - Normal in a male F344/N rat from a chronic study. A normal adrenal gland at the same magnification as Figure 5 6 is shown for comparison. M = medulla.
    Adrenal gland, Cortex - Normal in a male F344/N rat from a chronic study. A normal adrenal gland at the same magnification as Figure 6 is shown for comparison.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    Veterinary Pathologist, In Vivo Animal Core
    Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist/Assistant Pathology Program Manager
    Comparative Molecular Pathology Division
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Gordon Flake, MD
    Staff Scientist
    NTP Pathologist
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC