Endocrine System

Adrenal Gland, Cortex - Vacuolization, Cytoplasmic

    Narrative
    Adrenal gland, Cortex - Vacuolization, Cytoplasmic in a female F344/N rat from a chronic study. A large focus of vacuolated cells (CV) in the zona fasciculata causes little if any compression of the adjacent cortex.
    Adrenal gland, Cortex - Vacuolization, Cytoplasmic in a female F344/N rat from a chronic study (higher magnification of Figure 1). A large focus of cells (CV) in the zona fasciculata with variably sized vacuoles.
    Adrenal gland, Cortex - Vacuolization, Cytoplasmic in a male F344/N rat from a subchronic study. Diffuse cytoplasmic vacuolization is present predominantly in the zonae fasciculata and glomerulosa.
    Adrenal gland, Cortex - Vacuolization, Cytoplasmic in a male F344/N rat from a subchronic study (higher magnification of Figure 3). The cells of the zonae fasciculata and glomerulosa contain variably sized vacuoles.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    Veterinary Pathologist, In Vivo Animal Core
    Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist/Assistant Pathology Program Manager
    Comparative Molecular Pathology Division
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Gordon Flake, MD
    Staff Scientist
    NTP Pathologist
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC