Endocrine System

Adrenal Gland, Cortex, X-Zone - Atrophy

    Narrative
    Adrenal gland, Cortex, X-zone - Normal in a female B6C3F1/N mouse from a subchronic study. Adrenal gland with moderate numbers of vacuolated cells in an age-matched control virgin female is shown for comparison with Figure 3. M = medulla, XZ = X-zone, ZF = zona fasciculata.
    Adrenal gland, Cortex, X-zone - Normal in a female B6C3F1/N mouse from a subchronic study (higher magnification of Figure 1). Adrenal gland in an age-matched control virgin female is shown for comparison with Figure 4. M = medulla; XZ = X-zone.
    Adrenal gland, Cortex, X-zone - Atrophy in a virgin female B6C3F1/N mouse from a subchronic study. There is acceleration of X-zone (XZ) regression characterized by narrowing of the X-zone compared with Figure 1. M = medulla, ZF = zona fasciculata.
    Adrenal gland, Cortex, X-zone - Atrophy in a virgin female B6C3F1/N mouse from a subchronic study (higher magnification of Figure 3). There is increased degeneration and necrosis of the X-zone (XZ) cells compared with Figure 2.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    Veterinary Pathologist, In Vivo Animal Core
    Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist/Assistant Pathology Program Manager
    Comparative Molecular Pathology Division
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Gordon Flake, MD
    Staff Scientist
    NTP Pathologist
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC