Adrenal Gland - Cyst

Adrenal gland, Cortex - Cyst in a female B6C3F1/N mouse from a chronic study. An adrenal cortical cyst (C), filled with amorphous pale eosinophilic material, compresses adjacent cortex and medulla.
Figure 1 of 3

Adrenal gland, Cortex - Cyst in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). A single layer of well-differentiated, low columnar epithelial cells (arrow) lines an adrenocortical cyst.
Figure 2 of 3
comment:
Adrenal cysts ( Figure 1




recommendation:
Adrenal gland cysts should be diagnosed only if they occur with treatment-related increased incidences. In these cases, they should be diagnosed but not assigned of a severity grade. When diagnosed, an appropriate site modifier (i.e., cortex or medulla) should be included in the diagnosis to indicate the location of the cyst.references:
National Toxicology Program. 1993. NTP TR-434. Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CAS No. 106-99-0) in B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/6012
Nyska A, Maronpot RR. 1990. Adrenal gland. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 509-536. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Web page last updated on: January 02, 2015