Endocrine System

Adrenal Gland - Hyperplasia

    Narrative
    Adrenal gland, Cortex - Hyperplasia in a male Sprague-Dawley rat from a chronic study. There are two adjacent foci of hyperplasia (H) in the zona fasciculata.
    Adrenal gland, Cortex - Hyperplasia in a male Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). The foci of hyperplasia (H) are rounded, circumscribed areas of increased cellularity.
    Adrenal gland, Cortex - Hyperplasia in a female Sprague-Dawley rat from a chronic study. There is a circumscribed but noncompressive focus of hyperplasia (H) in the zona fasciculata.
    Adrenal gland, Cortex - Hyperplasia in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 3). The cells in this hyperplastic lesion (H) are smaller and more closely packed than those in the adjacent normal cortex.
    Adrenal gland, Cortex - Hyperplasia in a female F344/N rat from a chronic study. There is a hyperplastic lesion (H) in which cortical cells are increased in number but are smaller in size than adjacent normal cortical cells (NC).
    Adrenal gland, Cortex - Hyperplasia in a female F344/N rat from a chronic study. The hyperplastic lesion (H) has an increased number of cells that are smaller than adjacent normal cortical cells (NC).
    Adrenal gland, Medulla - Hyperplasia in a male B6C3F1/N mouse from a chronic study. There is a small, noncompressive focus of hyperplastic medullary cells at the corticomedullary junction (arrow). M = medulla.
    Adrenal gland, Medulla - Hyperplasia in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). The hyperplastic cells (arrow) are increased in number but are smaller and more basophilic than adjacent normal medullary cells (M).
    Adrenal gland, Medulla - Hyperplasia in a male F344/N rat from a chronic study. There is focal hyperplasia (arrow) deep in the medulla (M).
    Adrenal gland, Medulla - Hyperplasia in a male F344/N rat from a chronic study (higher magnification of Figure 9). The hyperplastic cells (H) are smaller (so the nuclei appear more crowded) and more basophilic than the adjacent normal medullary cells (M).

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    Veterinary Pathologist, In Vivo Animal Core
    Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist/Assistant Pathology Program Manager
    Comparative Molecular Pathology Division
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Gordon Flake, MD
    Staff Scientist
    NTP Pathologist
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC