Adrenal Gland - Mineralization

comment:
Mineralization in the adrenal gland ( Figure 1

Mineralization is characterized as variably sized, discrete aggregates of finely to coarsely granular dark basophilic material ( Figure 1


recommendation:
If mineralization of the adrenal gland occurs as a primary, treatment-related change, it should be diagnosed and assigned a severity grade and site modifier (i.e., cortex, medulla, or capsule). Mineralization that is a feature of another pathologic process (e.g., fibrosis or thrombosis) should not be diagnosed separately, unless warranted by severity.references:
Frith CH, Botts S, Jokinen MP, Eighmy JJ, Hailey JR, Morgan SJ, Chandra M. 2000. Non-proliferative lesions of the endocrine system in rats, E-1. In: Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC. Full Text: https://www.toxpath.org/docs/SSNDC/EndocrineNonprolifRat.pdf
Hamlin MH, Banas DA. 1990. Adrenal gland. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 501-518. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
National Toxicology Program. 1999. NTP TR-481. Toxicology and Carcinogenesis Studies of Oleic Acid Diethanolamine Condensate (CAS No. 93-83-4) in F344/N Rats and B6C3F1 Mice (Dermal Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/9764
National Toxicology Program. 2007. NTP TR-543. Toxicology and Carcinogenesis Studies of α-Methylstyrene (CAS No. 98-83-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/28010
Web page last updated on: January 02, 2015