Endocrine System

Adrenal Gland - Necrosis

    Narrative
    Adrenal gland, Cortex - Necrosis in a female B6C3F1 mouse from a subchronic study. Diffuse cortical necrosis involves primarily the zona fasciculata.
    Adrenal gland, Cortex - Necrosis in a female B6C3F1 mouse from a subchronic study (higher magnification of Figure 1). The zona fasciculata is collapsed due to necrosis of cortical cells (Ne).
    Adrenal gland, Cortex - Necrosis in a female B6C3F1 mouse from a subchronic study (higher magnification of Figure 1). There is loss of cellular detail, fragmented cortical cells, and amorphous debris in the zona fasciculata (Ne).
    Adrenal gland, Cortex - Necrosis in a female Sprague-Dawley rat from a chronic study. There is focal cortical necrosis in the zona fasciculata (arrow).
    Adrenal gland, Cortex - Necrosis in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 4). There is a focal area in the zona fasciculata in which the normal architecture is disrupted and replaced by necrotic cells (arrow) and amorphous debris.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    Veterinary Pathologist, In Vivo Animal Core
    Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist/Assistant Pathology Program Manager
    Comparative Molecular Pathology Division
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Gordon Flake, MD
    Staff Scientist
    NTP Pathologist
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC