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Pancreatic Islets - Angiectasis

Image of angiectasis in the pancreatic islet from a male F344/N rat in a chronic study
Pancreatic islet - angiectasis. Irregularly dilated spaces in this islet contain plasma and erythrocytes in a male F344/N rat from a chronic study.
Figure 1 of 4
Image of angiectasis in the pancreatic islet from a male F344/N rat in a chronic study
Pancreatic islet - angiectasis. Dilated spaces in this islet contain erythrocytes in a male F344/N from a chronic study.
Figure 2 of 4
Image of angiectasis in the pancreatic islet from a male B6C3F1 mouse in a chronic study
Pancreatic islet - angiectasis. Dilated vascular channels in this islet contain erythrocytes in a male B6C3F1 mouse from a subchronic study.
Figure 3 of 4
Image of angiectasis in the pancreatic islet from a male F344/N rat in a chronic study
Pancreatic islet - angiectasis. Dilated vascular channels in this islet contain erythrocytes and some hemosiderin pigment in a male F344/N rat from a chronic study.
Figure 4 of 4
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comment:

Angiectasis typically involves irregular dilated spaces that contain erythrocytes and/or plasma with a negligible endothelial cell lining. This is a spontaneous change with no known association with, or exacerbation by, treatment. Typically only one affected islet is seen in a section. There may also be hemosiderin pigment along with erythrocytes ( Figure 4image opens in a pop-up window ).

recommendation:

When present, this change should be diagnosed and graded. A severity grade will most often be minimal if the angiectasis is not widespread. If angiectasis or related changes are observed in other tissues, a comment to this effect should be added to the pathology narrative. If hemosiderin is present, a concurrent diagnosis of pigment is not necessary.

references:

Boorman GA, Sills RC. 1999. Exocrine and endocrine pancreas. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 185-206.
Abstract: http://www.cacheriverpress.com/books/pathmouse.htm