Endocrine System

Pancreatic Islets - Hyperplasia

    Narrative
    Pancreatic islet - normal. Normal islets in a control male B6C3F1 mouse from a chronic study.
    Pancreatic islet - hyperplasia. Section of pancreas represents mild islet hyperplasia in a control male B6C3F1 mouse from the same chronic study as in Figure 1.
    Pancreatic islet - hyperplasia. Section of pancreas represents mild islet hyperplasia in a control male B6C3F1 mouse from the same chronic study as in Figure 1.
    Pancreatic islet - hyperplasia. Three large hyperplastic islets are present in the pancreas in a male B6C3F1 mouse from a chronic study.
    Pancreatic islet - hyperplasia. Higher magnification of one of the hyperplastic islets in Figure 4, in a male B6C3F1 from a chronic study.
    Pancreatic islet - hyperplasia. Higher magnification of the hyperplastic islet in Figure 5, in a male B6C3F1 mouse from a chronic study. Note the lack of compression of the adjacent acinar parenchyma.
    Pancreatic islet - hyperplasia. Several adjacent coalescing hyperplastic islets are present in the pancreas in a male F344/N rat from a chronic study.
    Pancreatic islet - hyperplasia. This higher magnification of Figure 7 shows coalesced hyperplastic islets with occasional trapped acinar cells within the hyperplastic islet tissue in a male F344/N rat from a chronic study.
    Pancreatic islet - hyperplasia. Hyperplastic islet tissue with an irregular border is present in the pancreas in a male F344/N rat from a chronic study.

    Authors

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist
    Assistant Pathology Program Manager
    Integrated Laboratory Systems, Inc. Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC