Endocrine System

Parathyroid Gland - Syncytial Giant Cell

    Narrative
    Parathyroid Gland - Syncytial giant cell in a male F344/N rat from a subchronic study. A syncytial cell formed by fusion of adjacent chief cells is recognized by multiple nuclei and eosinophilic cytoplasm (arrow).
    Parathyroid Gland - Syncytial giant cell in a male F344/N rat from a subchronic study. Higher magnification of Figure 1 showing the multinucleated syncytial cell with eosinophilic cytoplasm formed by fusion of adjacent chief cells (arrow).

    Authors

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist/Assistant Pathology Program Manager
    Comparative Molecular Pathology Division
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC