Pituitary Gland, Rathke's Cleft - Dilation


comment:
Dilated persistent Rathke’s clefts are relatively common in rats and typically contain eosinophilic colloid-like proteinaceous material. Cholesterol clefts (arrow, Figure 1


recommendation:
Since chronic studies may incorporate in utero exposure, developmental alterations potentially related to treatment could influence the ultimate presence and appearance of Rathke’s cleft. Thus, this change should be documented when present. A severity grade is appropriate if there is a potential treatment-related effect on the occurrence or severity of this change. Hemorrhage or cholesterol clefts within the dilated Rathke’s cleft should not be diagnosed separately unless warranted by severity.related links:
Pituitary Gland - Cystreferences:
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Web page last updated on: August 08, 2014