Endocrine System

Thyroid Gland, Follicle, Epithelium - Hyperplasia

    Narrative
    Thyroid gland, Follicle, Epithelium - Hyperplasia in a male B6C3F1 mouse from a chronic study. Proliferative projections of hyperplastic epithelium are present in a single follicle (arrow).
    Thyroid gland, Follicle, Epithelium - Hyperplasia in a male B6C3F1 mouse from a chronic study. Higher magnification of Figure 1 shows the proliferative projections of hyperplastic epithelium in more detail.
    Thyroid gland, Follicle, Epithelium - Hyperplasia in a male F344/N rat from a subchronic study. Some degree of hypertrophy is present in this example of minimal epithelial hyperplasia.
    Thyroid gland, Follicle, Epithelium - Hyperplasia in a male F344/N rat in a subchronic study. There is minimal hyperplasia of the follicular epithelium with crowding of the nuclei and minimal protrusion into the follicular lumen.

    Authors

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC