Thyroid Gland, Follicular Cell - Hypertrophy



comment:
In follicular cell hypertrophy, thyroid follicles may be lined by cuboidal to columnar epithelium with central follicles tightly packed and smaller than normal ( Figure 1




recommendation:
Thyroid follicular cell hypertrophy should be diagnosed and graded when present. The pathology narrative can describe the nature of the hypertrophic follicular epithelium and whether bilateral, accompanied by follicular hyperplasia, or associated with alterations in colloid.references:
Capen CC, Martin SL. 1989. The effects of xenobiotics on the structure and function of thyroid follicular and C-cells. Toxicol Pathol 17:266-293. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/2675279
Capen CC, DeLellis RA, Yarrington JT. 2002. Endocrine system. In: Handbook of Toxicologic Pathology, Vol 2 (Haschek WM, Rousseaux CG, Wallig MA, eds). Academic Press, New York, 681–783. Abstract: http://www.sciencedirect.com/science/book/9780123302151
Collins WT, Capen CC, Kasza L, Carter C, Dailey RE. 1977. Effect of polychlorinated biphenyl (PCB) on the thyroid gland of rats. Ultrastructural and biochemical investigations. Am J Pathol 89:119-136. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/199066
Greaves P. 2007. Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation, 3rd ed. Academic Press, Amsterdam, 819-839. Abstract: http://www.sciencedirect.com/science/book/9780444527714
Hardisty JF, Boorman GA. 1990. Thyroid gland. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 519–536. Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Hood A, Hashmi R, Klaassen CD. 1999. Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy. Toxicol Appl Pharmacol 160:163-170. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10527915
Stevens JT. 1985. Effect of chemicals on the thyroid gland. In: Endocrine Toxicology (Thomas JA, Korach KS, McLachlan JA, eds). Raven Press, New York, 135–147. Abstract: http://informahealthcare.com/doi/book/10.3109/9781420093100
Web page last updated on: August 08, 2014