Clitoral Gland, Duct - Dilation











comment:
Clitoral gland duct dilation (
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) is a common incidental finding in aging rodents. It has also been induced with administration of androgenic steroids. Dilation of the ducts of the clitoral glands is frequently accompanied by atrophy of the glandular tissue. The epithelial lining of smaller ducts may be cuboidal, flattened, or keratinized squamous epithelium. When this condition is severe, the dilated ducts may occupy the majority of the clitoral gland, with remnants of the acinar tissue evident between the dilated ducts, and the glands may be grossly enlarged due to duct dilation. Care must be taken in diagnosing this lesion in mice because mice typically have very cavernous ducts with little glandular tissue.
recommendation:
Clitoral gland - Duct, Dilation should always be diagnosed and given a severity grade when it is considered a primary change. Clitoral gland atrophy caused by duct dilation does not need to be diagnosed separately but can be described in the narrative.references:
Brix AE, Nyska A, Haseman JK, Sells DM, Jokinen MP, Walker NJ. 2005. Incidences of selected lesions in control female Harlan Sprague-Dawley rats from two-year studies performed by the National Toxicology Program. Toxicol Pathol 33:477-483. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/16036865
Copeland-Haines D, Eustis SL. 1990. Specialized sebaceous glands. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 279-293.
National Toxicology Program. 1999. NTP TR-485. Toxicology and Carcinogenesis Studies of Oxymetholone (CAS No. 434-07-1) in F344/N Rats and Toxicology Studies of Oxymetholone in B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/9771
National Toxicology Program. 2006. NTP TR-521. Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/9303
National Toxicology Program. 2010. NTP TR-558. Toxicology and Carcinogenesis Studies of 3,3',4,4'-Tetrachloroazobenzene (TCAB) (CAS No. 14047-09-7) in Harlan Sprague-Dawley Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/33564
Seely JC, Boorman GA. 1991. Mammary gland and specialized sebaceous glands. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 613-635.
Web page last updated on: November 20, 2015