Reproductive System, Female

Clitoral Gland, Duct - Dilation

    Narrative
    Clitoral gland, Duct - Dilation, Marked in a female Sprague-Dawley rat from a chronic study. The central duct is markedly dilated and filled with eosinophilic material.
    Clitoral gland, Duct - Dilation, Marked in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). Squamous epithelium lines the dilated duct, and eosinophilic debris is evident in the lumen.
    Clitoral gland, Duct - Dilation, Marked in a female B6C3F1/N mouse from a chronic study. The markedly dilated central duct is filled with eosinophilic material and occupies much of the clitoral gland.
    Clitoral gland, Duct - Dilation, Marked in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). Squamous epithelium lines the dilated duct, and eosinophilic debris is evident centrally in the lumen.
    Clitoral gland, Duct - Dilation, Marked in a female F344/N rat from a chronic study. The central duct is markedly dilated and contains amorphous eosinophilic material.
    Clitoral gland - Atrophy in a female F344/N rat from a chronic study (higher magnification of Figure 4). There is an increase in intervening fibrous connective tissue with a reduction in glandular tissue.
    Clitoral gland, Duct - Dilation, Marked in a female F344/N rat from a chronic study (higher magnification of Figure 5). The dilated duct contains amorphous eosinophilic material and is lined by squamous epithelium.
    Clitoral gland, Duct - Dilation, in a female B6C3F1/N mouse from a subchronic study. Dilated ducts comprise the majority of the clitoral gland.
    Clitoral gland, Duct - Dilation, Bilateral, in a female B6C3F1/N mouse from a subchronic study. Dilated ducts comprise the majority of the clitoral gland.
    Clitoral gland, Duct - Dilation in a female B6C3F1/N mouse from a subchronic study (higher magnification of Figure 8). There are several dilated ducts and intervening acinar tissue.
    Clitoral gland, Duct - Dilation in a female F344/N rat from a subchronic study. The dilated ducts are surrounded by acinar tissue.
    Clitoral gland, Duct - Dilation in a female B6C3F1/N mouse from a subchronic study. The ducts have a flattened epithelial lining and contain scant luminal debris.

    Authors

    Gabrielle Willson, BVMS, Dip RC Path, FRC Path, MRCVS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Karen Y. Cimon, DVM, MS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Gordon Flake, MD
    Staff Scientist
    NTP Pathologist
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Karen S. Regan, DVM, DABT, DACVP
    Pathologist
    Regan Path/Tox Services, Inc.
    Ashland, OH  

    Darlene Dixon, DVM, PhD, DACVP, Fellow, IATP
    Group Leader, Molecular Pathogenesis Group
    National Toxicology Program Laboratory
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC