Reproductive System, Female

Ovary, Corpus Luteum - Cyst

    Narrative
    Ovary, Corpus luteum - Cyst in a female F344/N rat from a subchronic study. The cyst is thick walled and fluid filled, and a secondary follicle lined by dark basophilic granulosa cells is present in the adjacent parenchyma.
    Ovary, Corpus luteum - Cyst in a female F344/N rat from a subchronic study (higher magnification of Figure 1). The cyst wall is composed of several layers of luteinized granulosa cells containing foamy, vacuolated, eosinophilic cytoplasm, and the lumen contains acellular eosinophilic material.
    Ovary, Corpus luteum - Cyst in a female F344/N rat from a chronic study. The cyst is at the periphery of the ovary.
    Ovary, Corpus luteum - Cyst in a female F344/N rat from a chronic study (higher magnification of Figure 3). There is eosinophilic fluid within the cyst.

    Authors

    Gabrielle Willson, BVMS, Dip RC Path, FRC Path, MRCVS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Karen Y. Cimon, DVM, MS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Karen S. Regan, DVM, DABT, DACVP
    Pathologist
    Regan Path/Tox Services, Inc.
    Ashland, OH  

    Darlene Dixon, DVM, PhD, DACVP, Fellow, IATP
    Group Leader, Molecular Pathogenesis Group
    National Toxicology Program Laboratory
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC