Reproductive System, Female

Ovary, Interstitial Cell - Hyperplasia

    Narrative
    Ovary, Interstitial cell - Hyperplasia in a female F344/N rat from a subchronic study. Clusters of pale interstitial cells are interspersed among follicles.
    Ovary, Interstitial cell - Hyperplasia in a female F344/N rat from a subchronic study (higher magnification of Figure 1). There are cords and nests of hyperplastic interstitial cells, which are composed of large polyhedral cells with pale eosinophilic granular cytoplasm and a central nucleus.

    Authors

    Gabrielle Willson, BVMS, Dip RC Path, FRC Path, MRCVS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Karen Y. Cimon, DVM, MS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Karen S. Regan, DVM, DABT, DACVP
    Pathologist
    Regan Path/Tox Services, Inc.
    Ashland, OH  

    Darlene Dixon, DVM, PhD, DACVP, Fellow, IATP
    Group Leader, Molecular Pathogenesis Group
    National Toxicology Program Laboratory
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC