Ovary, Interstitial Cell - Hyperplasia
Typically in interstitial cell hyperplasia many variably sized clusters of pale-staining cells are interspersed among several follicles in various stages of development, including large atretic follicles, mature corpora lutea, areas of pigment deposition, and congested blood vessels ( Figure 1 ). Cords and nests of hyperplastic interstitial cells are composed of large polyhedral cells with pale eosinophilic granular cytoplasm and central nuclei ( Figure 2 ). Ovarian interstitial cell hyperplasia is a nonneoplastic proliferation of cellular components of the interstitial gland, derived from atretic follicles, corpora lutea, or ovarian stromal cells. This is a common aging change in rats and mice. It may also be induced by treatment with certain chemicals, such as gonadotropins and some organophosphate compounds.
Ovary, Interstitial cell - Hyperplasia should be diagnosed and graded whenever present.
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